KRAS G12C + Sotorasib

Interactive Drug Resistance Visualizer (PDB: 6OIM)

Navigate

Drag Orbit / rotate the molecule

Scroll Zoom in / out

Right-drag Pan the view

Representation

1 Ball-and-stick (default)

2 Wireframe (bonds only)

3 Space-fill (van der Waals spheres)

P Toggle binding pocket vs full protein (1300 atoms)

Experiments

B Base view - protein + drug in pocket

M Resistance mutations - shows where drug resistance occurs

C Drug comparison - sotorasib vs adagrasib

D Dynamics - BioEmu conformational ensemble

E Evolution - ESM mutation sensitivity heatmap

F Function - DeepFRI functional importance heatmap

Mutation Scanner (in Mutations mode)

4 Y96D - cross-resistant (red glow = both drugs fail)

5 H95D - differential (green = sotorasib still works!)

0 Clear mutation highlight

Tools

R Reset view to default position

Atom labels: Hover atoms to see info. "A" = chain A (the protein chain ID in the crystal structure). Colors: gray=Carbon, red=Oxygen, blue=Nitrogen, yellow=Sulfur, green=Fluorine/Chlorine.

Atom Elements

Carbon (C)

Oxygen (O)

Nitrogen (N)

Sulfur (S)

Fluorine (F)

Protein vs Drug

Protein (grey, transparent)

Drug (blue glow, larger)

Interaction Lines

H-Bond (blue dashed)

Hydrophobic (yellow dashed)

Salt Bridge (red dashed)